images/spacer.gif - 54 Bytes ERIC A LIVESAY, PH.D.

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Eric A. Livesay, Ph.D., brings to Hecate a wide range of research and development experience obtained during his doctoral work, 2 post-doctoral positions and his time as a Senior Research Scientist at a national laboratory.

Eric joined Hecate Software as Chief Scientific Officer in 2008. Since that time he has been the lead developer on several projects, writing code in both C# and Visual Basic. Eric first worked at Hecate from 1993 until 1995 as a developer of C and C++ programs on projects for the Corps of Engineers and various companies in the oil and gas industry.

From 2003 until 2008 Eric worked in the proteomics group of Richard Smith, Ph.D., first as a post-doctoral researcher (2003-2004) and then as a Senior Research Scientist (2004-2008) in the Environmental Molecular Sciences Laboratory (EMSL) at Pacific Northwest National Laboratory (PNNL) in Richland, Washington. Eric functioned as a central resource for the high throughput proteomic analysis effort at PNNL. He designed and developed fully automated capillary liquid chromatography (LC) platforms. Those platforms were interfaced with a variety of mass spectrometers via electrospray ionization (ESI).

During his first postdoctoral position, from 2000 to 2003, Eric led an interdisciplinary team in the development of a prototype high-throughput DNA synthesizer while working at the University of Texas Southwestern Medical Center (UTSW) in Dallas, Texas. Eric wrote the control software for the DNA synthesizer in Visual Basic and interfaced it with various off-the-shelf hardware components (e.g., electromechanical relays and linear motion tables). He also designed and machined several pieces of custom hardware for the prototype.

Eric's doctoral work was performed from 1995 to 2000 at the Univeristy of Texas at Arlington (UTA) under the supervision of Roy N. West, Ph.D. He made measurements of the Fermi surface of the colossal magnetoresistive material La(0.7)Sr(0.3)MnO(3) using the method of two-dimensional angular correlation of annihilation radiation (2D-ACAR). These measurements provided needed experimental support for existing theoetical descriptions of that material. During this time Eric participated in magnetic Compton scattering measurements on the same material at the European Synchrotron Radiation Facility (ESRF). Eric obtained his B.S. degreen in physics from UTA in 1995.

PUBLICATIONS

B. Ham, F. Yang, J., H. Jayachandran, N. Jaitly, M. Monroe, M A. Gritsenko, E. A. Livesay , R. Zhao, S. O. Purvine, D. Orton, J. N. Adkins, D. G. Camp, S. Rossie, R. D. Smith, The influence of sample preparation and replicate analyses on HeLa cell phosphoproteome coverage, J. Prot. Res. 7, 2215-2221, 2008

E. A. Livesay, K. Tang, B. K. Taylor, M. A. Buschbach, D. F. Hopkins, B. L. Lamarche, R. Zhao, Y. Shen, D Orton, R. J. Moore, R. T. Kelly, H. R. Udseth, R. D. Smith, Fully automated four-column capillary LC-MS system for maximizing throughput in proteomic analyses, Anal. Chem. 80, 294-302, 2007

J. Ding, T. O. Metz, C. M. Sorensen, Q. Zhang, H. Jiang, N. Jaitly, E. A. Livesay, Y. Shen, R. D. Smith, Capillary LC coupled with high-mass measurement accuracy mass spectrometry for metabolic profiling, Anal. Chem. 79, 6081-6093, 2007

V. A. Petyuk, W. J. Qian, M. H. Chin, H. Wang, E. A. Livesay, M. E. Monroe, J. A. Adkins, N. Jaitly, D. J. Anderson, D. G. Camp II, D. J. Smith, R. D. Smith, Spatial mapping of protein abundances in the mouse brain by voxelation integrated with high-throughput liquid chromatography-mass spectrometry, Genome Res. 17, 328-336, 2007

Y. Shen, R. Zhang, R. J. Moore, J. Kim, T. O. Metz, K. K. Hixson, R. Zhao, E. A. Livesay, H. R. Udseth, R. D. Smith, Automated 20 kpsi RPLC-MS and MS/MS with chromatographic peak capacities of 1000-1500 and capabilities in proteomics and metabolomics, Anal chem., 77, 3090-3100, 2005

Y. H. S. Liu, E. A. Livesay, K. J. Luebke, S. A. Johnston, A simple method to make a membrane with differential permeable regions, J Membrane Sci., 214, 95-101, 2003

E. A. Livesay, Y. H. Liu, K. J. Luebke, J. Irick, Y. Belosludtsev, S. Rayner, R. Balog, S. A. Johnston, A scalable high-throughput chemical synthesizer, Genome Res., 12, 1950-1960, 2002

E. A. Livesay, R. N. West, S. B. Dugdale, G. Santi, T. Jarlborg , A spin-polarized 2D-ACAR study of the colossal magnetoresistive material La0.7Sr0.3MnO3, Mater. Sci. Forum, 363, 576-678, 2001

E. A. Livesay, R. N. West, S. B. Dugdale, G. Santi and T. Jarlborg, Fermi-surface of the colossal magnetoresistance perovskite La0.7Sr0.3MnO3, J. Phys. Condens. Matt., 11, L29-L285, 1999

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