Software Engineer, Ph.D.

Brian LaMarche joined Hecate Software in 2014 and is now the lead engineer on the GreenLight Software Suite.  He spent his early career at Pacific Northwest National Laboratory (PNNL) leading projects in laboratory automation, image processing, microscopy, computational mass spectrometry data analysis, user interfaces, and large-scale data processing. He played a pinnacle role in designing real-time processing software for the Juvenile Salmon Acoustic Tracking System (JSATS) project which was capable of capturing petabytes of data.  Brian is a believer of flexible plug-in software architectures, as demonstrated by the automation of liquid chromatography mass spectrometry (LCMS) systems. This software allows researchers to quickly integrate heterogeneous hardware, reconfigure experimental procedures, and take to full automation rapidly.  In 2013, Brian was an integral part of a team that won an R&D 100 award for the development of an instrument and analysis software that leads to rapid medical and environmental testing. 

Brian received his B.S. with Honors in Computer Science in 2004 from Washington State University.  He received his Doctorate in Computer Science from Washington State University Tri-Cities (WSU-TC) in 2016 for his research that was focused on the alignment and correlation of hundreds of proteomic and metabolomic datasets using unsupervised learning techniques. 

From 2011 to 2015, Brian was an adjunct professor at WSU-TC where he taught software courses to undergraduates in software design, testing, and advanced data structures.  During his tenure, he designed advanced teaching aides which integrated modern embedded hardware, including the Raspberry Pi and Arduino, into his curriculum.  He works with his local area high schools to help integrate computer science into their STEM curriculums.

Brian Lamarche
1. Lamarche BL, KL Crowell, N Jaitly, VA Petyuk, AR Shah, AD Polpitiya, JD Sandoval, GR Kiebel, ME Monroe, SJ Callister, TO Metz, GA Anderson, and RD Smith. 2013. "MultiAlign: a multiple LC-MS analysis tool for targeted omics analysis." BMC Bioinformatics
2. Amidan BG, DJ Orton, BL Lamarche, ME Monroe, RJ Moore, RD Smith, LH Sego, SH Payne, and MF Tardiff. 2013. "Signatures for Mass Spectrometry Data Quality." PNNL-SA-97216, Pacific Northwest National Laboratory, Richland, WA. [Unpublished – Submitted to J
3. Crowell KL, GW Slysz, ES Baker, BL Lamarche, ME Monroe, YM Ibrahim, SH Payne, GA Anderson, and RD Smith. 2013. "LC-IMS-MS Feature Finder: Detecting Multidimensional Liquid Chromatography, Ion Mobility, and Mass Spectrometry Features in Complex Datasets
4. Crowell KL, ES Baker, SH Payne, YM Ibrahim, ME Monroe, GW Slysz, BL Lamarche, VA Petyuk, PD Piehowski, WF Danielson, III, GA Anderson, and RD Smith. 2013. "Increasing Confidence of LC-MS Identifications by Utilizing Ion Mobility Spectrometry." Internat
5. Leach FE, III, GA Anderson, RV Norheim, RJ Ewing, BL Lamarche, JH Futrell, YM Ibrahim, RD Smith, EW Robinson, DW Koppenaal, AV Tolmachev, IK Webb, TY Lin, and L Pasa-Tolic. 2013. "PROGRESS TOWARDS ENHANCED HIGH FIELD FT-ICR MS AT EMSL." Presented by Fr
6. Lamarche BL, KL Crowell, SH Payne, VA Petyuk, ME Monroe, SJ Callister, TO Metz, J Miller, RR Lewis, GA Anderson, and RD Smith. 2013. "MultiAlign- a scalable and flexible infrastructure for label-free quantitation." Presented by Brian LaMarche at Cascad
7. Kim JA, KJ Auberry, BL Lamarche, CM Woodley, GR Ploskey, and MA Weiland. 2013. "Form, Function and Structuring Large Multi-year Database of Acoustic Monitoring (MyDAM)." Presented by Jina Kim at International Conference on Engineering and Ecohydrology
8. Woodley CM, AR Phillips, BL Lamarche, NG Trimble, and MA Weiland. 2013. "FishSuite! Software for annotating, photographing, tracking, and reporting on fish and physiological condition." Presented by Mark A. Weiland at International Conference on Engine
9. Lamarche BL, MA Weiland, CM Woodley, EY Choi, AE Flory, NG Trimble, AR Phillips, DA Parrs, AI Thronas, MC Richart, KJ Auberry, and MB Eppard. 2012. "A Fisheries Information Management System for Petabyte Scale Telemetry." Presented by Brian LaMarche at
10. Trimble NG, AR Phillips, CM Woodley, BL Lamarche, and MA Weiland. 2012. "FishSuite - Software for Annotating, Photographing, Tracking, and Reporting on Physiological Condition for Telemetry Related Studies." Presented by Nathan Trimble at 142nd Annual
11. Weiland MA, Z Deng, TA Seim, BL Lamarche, EY Choi, T Fu, TJ Carlson, AI Thronas, and MB Eppard. 2011. "A cabled acoustic telemetry system for detecting and tracking juvenile salmon: Part 1. Engineering design and instrumentation." Sensors 11(6):5645-5
12. Deng Z, MA Weiland, T Fu, TA Seim, BL Lamarche, EY Choi, TJ Carlson, and MB Eppard. 2011. "A Cabled Acoustic Telemetry System for Detecting and Tracking Juvenile Salmon: Part 2. Three-Dimensional Tracking and Passage Outcomes." Sensors 11(6):5661-5676
13. Baker ES, EA Livesay, DJ Orton, RJ Moore, WF Danielson, DC Prior, YM Ibrahim, BL Lamarche, AM Mayampurath, AA Schepmoes, DF Hopkins, K Tang, RD Smith, and ME Belov. 2010. "An LC-IMS-MS Platform Providing Increased Proteome Coverage for High-Throughput
14. Marginean I, RT Kelly, RJ Moore, DC Prior, BL Lamarche, K Tang, and RD Smith. 2009. "Selection of the Optimum Electrospray Voltage for Gradient Elution LC-MS Measurements." Journal of the American Society for Mass Spectrometry 20(4):682-688
15. Lamarche BL, RR Lewis, DC Girvin, and JP McKinley. 2008. "Automated Classification of Scanning Electron Microscope Particle Images using Morphological Analysis." Presented by Brian La Marche at American Geophysical Union Annual Meeting, San Francisco,
16. Livesay EA, K Tang, BK Taylor, MA Buschbach, DF Hopkins, BL Lamarche, R Zhao, Y Shen, D Orton, RJ Moore, RT Kelly, HR Udseth, and RD Smith. 2008. "Fully automated four-column capillary LC-MS system for maximizing throughput in proteomic analyses." Ana
17. Petyuk VA, MH Chin, W Qian, RJ Moore, HM Brewer, DJ Orton, EA Livesay, ME Monroe, JN Adkins, BL Lamarche, DG Camp, II, DJ Smith, and RD Smith. 2007. "A Novel Approach for Multiplex Imaging of Protein Abundances in Tissues and Organs: Initial Applicati
18. Lamarche BL, DF Hopkins, CO Hughes, TP McKenna, and EW Fulp. 2007. "A Network Layer for Teleoperations in High Speed Environments." Presented by Errin W. Fulp (Invited Speaker) at IEEE INFOCOM 2007 High-Speed Networks Workshop, Anchorage, AK on May 11
19. Perrine KA, BL Lamarche, DF Hopkins, SE Budge, L Opresko, HS Wiley, and MB Sowa. 2007. "High Speed Method for in Situ Multispectral Image Registration." Microscopy Research and Technique 70(4):382-389. doi:10.1002/jemt.20423
20. Perrine, K., Hopkins, D. F., LaMarche, B., and Sowa, M. B., Getting the Pixels in Line: A Real-time Image Processing System for Biology, Scientific Computing, October, 16-20 (2005).